Toll-like receptors (TLRs) are vital elements of the mammalian immune system that function
by recognizing pathogen-associated molecular patterns (PAMPs), bridging innate and …

Studies of “pre β” high density lipoprotein (HDL) and reconstituted HDL (rHDL) have
contributed to our understanding of the Reverse Cholesterol Transport pathway. The relative …

Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident,
CD8+ memory T cell (Trm) response. Trm cells so elicited act quickly upon reencounter with …

Lung-localized CD4 T cells play a critical role in the control of influenza virus infection and
can provide broadly protective immunity. However, current influenza vaccination strategies …

Nanolipoprotein particles (NLPs), a lipid bilayer-based nanoparticle platform, have recently
been developed for in vivo delivery of a variety of molecules of therapeutic interest, but their …

In vivo delivery of large RNA molecules has significant implications for novel gene therapy,
biologics delivery, and vaccine applications. We have developed cationic nanolipoprotein …

The present Porcine circovirus type 2 virus (PCV 2) vaccine adjuvants suffer from numerous
limitations, such as adverse effects, deficient cell-mediated immune responses, and …

Chlamydia trachomatis is a sexually transmitted bacterium that infects over 130 million
individuals worldwide annually. To implement a vaccine, we developed a cell-free co …

Nanolipoprotein particles (NLPs) are reconstituted high-density lipoproteins, consisting of a
phospholipid bilayer stabilized by an apolipoprotein scaffold protein. This class of …

MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters
on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR …