Careful consideration of how we approach design is crucial to all areas of biotechnology.
However, choosing or developing an effective design methodology is not always easy as …

The de novo synthesis of genomes has made unprecedented progress and achieved
milestones, particularly in bacteria and yeast. However, the process of synthesizing a …

After decades of development, DNA synthesis, assembly, and sequencing technologies
have reached a high level, allowing faster and cheaper acquirements of synthetic genes or …

Microbes have long provided us with important capabilities, and the genome engineering of
microbes has greatly empowered research and applications in biotechnology. This is …

We designed and synthesized synI, which is∼ 21.6% shorter than native chrI, the smallest
chromosome in Saccharomyces cerevisiae. SynI was designed for attachment to another …

In the field of synthetic biology, rapid advancements in DNA assembly and editing have
made it possible to manipulate large DNA, even entire genomes. These advancements have …

Engineering the genetic code of an organism provides the basis for (i) making any organism
safely resistant to natural viruses and (ii) preventing genetic information flow into and out of …

In a series of new papers published in Cell and Cell Genomics, an international consortium
has generated synthetic versions of all 16 yeast chromosomes as well as 1 synthetic …