The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain
injury, causes severe neurological symptoms such as sensory and motor deficits. Currently …

The microtubule (MT) cytoskeleton of a mature axon is maintained in a stabilized steady
state, yet after axonal injury it can be transformed into a dynamic structure capable of …

Background Automatic quantification of neuronal morphology from images of fluorescence
microscopy plays an increasingly important role in high-content screenings. However, there …

Axon growth is driven by the movement of a growth cone, a specialized sensory motile
structure located at the tip of a growing neurite. Although stalled retraction bulbs have long …

Contemporary research has revealed a great deal of information on the behaviours of
microtubules that underlie critical events in the lives of neurons. Microtubules in the neuron …

Background Endothelial cell (EC) released microvesicles (EMVs) can affect various target
cells by transferring carried genetic information. Astrocytes are the main components of the …

cAMP is a critical second messenger mediating activity-dependent neuronal survival and
neurite growth. We investigated the expression and function of the soluble adenylyl cyclase …

A variety of in vitro models have been developed to understand the mechanisms underlying
the regenerative failure of central nervous system (CNS) axons, and to guide pre-clinical …