The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Lysosomes are membrane‐bound vesicles that contain hydrolases for the degradation and
recycling of essential nutrients to maintain homeostasis within cells. Cancer cells have …

Macrophage‐stimulator of interferon genes (STING) signaling mediated sterile inflammation
has been implicated in various age‐related diseases. However, whether and how …

Resveratrol (RSV), a natural polyphenol, has been suggested to induce cell cycle arrest and
activate apoptosis‐mediated cell death in several cancer cells, including prostate cancer …

The global incidence of cardiac diseases is increasing, imposing a substantial
socioeconomic burden on healthcare systems. The pathogenesis of cardiovascular disease …

Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …

JCI - Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer
and brain metastases Go to JCI Insight About Editors Consulting Editors For authors Publication …

Advanced prostate cancers that progress to tumor metastases are often considered
incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other …

The smart strategy of cancer cells to bypass the caspase-dependent apoptotic pathway has
led to the discovery of novel anti-cancer approaches including the targeting of lysosomes …

A major player of vertebrate cell volume regulation is the volume-regulated anion channel
(VRAC), which conducts halide ions and organic osmolytes to counteract osmotic …