Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

Introduction: The concept of privileged structures is well known and is often used in the
process of drug design and development. Although its assumptions are not clear, its overall …

Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein
deletion and subsequent activation of the PI3K/Akt signaling pathway are common in …

At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …

CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …

Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved,
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …