Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation
PL Valenzuela, LM Ruilope… - European Heart …, 2023 - academic.oup.com
There is a pandemic of physical inactivity that appears to parallel the widespread
prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise …
prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise …
Fiber types in mammalian skeletal muscles
S Schiaffino, C Reggiani - Physiological reviews, 2011 - journals.physiology.org
Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …
during embryonic development by intrinsic myogenic control mechanisms and is later …
Exercise-stimulated ROS sensitive signaling pathways in skeletal muscle
J Bouviere, RS Fortunato, C Dupuy… - Antioxidants, 2021 - mdpi.com
Physical exercise represents a major challenge to whole-body homeostasis, provoking
acute and adaptative responses at the cellular and systemic levels. Different sources of …
acute and adaptative responses at the cellular and systemic levels. Different sources of …
Skeletal muscle mitochondrial remodeling in exercise and diseases
Z Gan, T Fu, DP Kelly, RB Vega - Cell Research, 2018 - nature.com
Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity
Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …
Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway
Y Ozaki, K Ohashi, N Otaka, H Kawanishi… - Nature …, 2023 - nature.com
To maintain and restore skeletal muscle mass and function is essential for healthy aging. We
have found that myonectin acts as a cardioprotective myokine. Here, we investigate the …
have found that myonectin acts as a cardioprotective myokine. Here, we investigate the …
Nutritional ketosis and mitohormesis: potential implications for mitochondrial function and human health
VJ Miller, FA Villamena, JS Volek - Journal of nutrition and …, 2018 - Wiley Online Library
Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …
species (ROS) and is involved in the etiology of many chronic diseases, including …
Transcriptional control of mitochondrial biogenesis and function
MB Hock, A Kralli - Annual review of physiology, 2009 - annualreviews.org
Mitochondria play central roles in energy homeostasis, metabolism, signaling, and
apoptosis. Accordingly, the abundance, morphology, and functional properties of …
apoptosis. Accordingly, the abundance, morphology, and functional properties of …
High-intensity interval training and moderate-intensity continuous training attenuate oxidative damage and promote myokine response in the skeletal muscle of ApoE …
L Wang, J Lavier, W Hua, Y Wang, L Gong, H Wei… - Antioxidants, 2021 - mdpi.com
The purpose of this study was to investigate the effects of high-intensity interval training
(HIIT) and moderate-intensity continuous training (MICT) on the skeletal muscle in …
(HIIT) and moderate-intensity continuous training (MICT) on the skeletal muscle in …
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
Z Gerhart-Hines, JE Dominy, SM Blättler… - Molecular cell, 2011 - cell.com
The NAD+-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of
the Sirtuin family that mediates homeostatic responses to certain physiological stresses such …
the Sirtuin family that mediates homeostatic responses to certain physiological stresses such …