[HTML][HTML] Macrophages in health and disease
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …
increasingly transparent over the last decade. But with the plethora of data comes a natural …
Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
[HTML][HTML] Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …
macrophages, and recruited monocyte-derived cells; together, they control brain …
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
F Leng, P Edison - Nature Reviews Neurology, 2021 - nature.com
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
The pivotal role of NF-kB in the pathogenesis and therapeutics of Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …
Immunotherapy for Alzheimer's disease: Targeting β-amyloid and beyond
C Song, J Shi, P Zhang, Y Zhang, J Xu, L Zhao… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the …
worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the …
[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
Microglia: agents of the CNS pro-inflammatory response
JA Rodríguez-Gómez, E Kavanagh… - Cells, 2020 - mdpi.com
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease
NM Lyra e Silva, RA Gonçalves, TA Pascoal… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) is associated with memory impairment and altered peripheral
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …
Brain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …