The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Congenital anomalies of the kidney and urinary tract (CAKUT) cover a wide range of
structural malformations that result from defects in the morphogenesis of the kidney and/or …

Haploinsufficiency is defined as a dominant phenotype in diploid organisms that are
heterozygous for a loss-of-function allele. Despite its relevance to human disease, neither …

Purpose: To provide practice recommendations for the diagnosis and management of
hypoparathyroidism in adults. Methods: Key questions pertaining to the diagnosis and …

Hereditary deafness has proved to be extremely heterogeneous genetically with more than
40 genes mapped or cloned for non-syndromic dominant deafness and 30 for autosomal …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Parathyroid hormone (PTH) is a potent pharmacologic inducer of new bone formation, but
no physiologic anabolic effect of PTH on adult bone has been described. We investigated …

GATA3 is an essential transcription factor that was first identified as a regulator of immune
cell function. In recent microarray analyses of human breast tumors, both normal breast …

During the past decades, remarkable progress has been made in our understanding of the
molecular basis of kidney diseases, as well as in the ability to pinpoint disease-causing …

CD4+ T helper cells regulate appropriate cellular and humoral immune responses to a wide
range of pathogens and get involved in many diseases progress. The balance of the earliest …