Practical guidance for clinical microbiology laboratories: mycobacteria

BA Forbes, GS Hall, MB Miller, SM Novak… - Clinical microbiology …, 2018 - Am Soc Microbiol
Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy,
Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most …

Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - Am Soc Microbiol
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

NC Bahr, E Nuwagira, EE Evans… - The Lancet infectious …, 2018 - thelancet.com
Summary Background WHO recommends Xpert MTB/RIF as initial diagnostic testing for
tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about …

Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics

PS Ramachandran, A Ramesh, FV Creswell… - Nature …, 2022 - nature.com
The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well
understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis …

[HTML][HTML] The current global situation for tuberculous meningitis: epidemiology, diagnostics, treatment and outcomes

JA Seddon, L Tugume, R Solomons… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Tuberculous meningitis (TBM) results from dissemination of M. tuberculosis to the
cerebrospinal fluid (CSF) and meninges. Ischaemia, hydrocephalus and raised intracranial …

Deciphering the role of nanoparticles for management of bacterial meningitis: an update on recent studies

N Sharma, I Zahoor, M Sachdeva… - … Science and Pollution …, 2021 - Springer
Meningitis is an inflammation of the protective membranes called meninges and fluid
adjacent the brain and spinal cord. The inflammatory progression expands all through …

Methods for rapid diagnosis of meningitis etiology in adults

V Poplin, DR Boulware, NC Bahr - Biomarkers in medicine, 2020 - Taylor & Francis
Infectious meningitis can be caused by viral, bacterial or fungal pathogens. Despite widely
available treatments, many types of infectious meningitis are still associated with significant …

Improved diagnostic sensitivity for tuberculous meningitis with Xpert® MTB/RIF of centrifuged CSF

NC Bahr, L Tugume, R Rajasingham… - … of tuberculosis and …, 2015 - ingentaconnect.com
BACKGROUND: TB meningitis (TBM) diagnosis is difficult and novel diagnostic methods are
needed. The World Health Organization recommends Xpert® MTB/RIF as the initial TBM …

[HTML][HTML] Challenges in the diagnosis of tuberculous meningitis

CF Palacios, PG Saleeb - Journal of clinical tuberculosis and other …, 2020 - Elsevier
Tuberculosis (TB) continues to pose a significant public health problem. Tuberculous
meningitis (TBM) is the most severe form of extra-pulmonary TB. TBM carries a high mortality …

Clinical application and evaluation of metagenomic next-generation sequencing in pathogen detection for suspected central nervous system infections

L Yuan, XY Zhu, LM Lai, Q Chen, Y Liu, R Zhao - Scientific Reports, 2024 - nature.com
Abstract Central nervous system Infections (CNSIs) is a disease characterized by complex
pathogens, rapid disease progression, high mortality rate and high disability rate. Here, we …