Gut microbiota profiling: metabolomics based approach to unravel compounds affecting human health

P Vernocchi, F Del Chierico, L Putignani - Frontiers in microbiology, 2016 - frontiersin.org
The gut microbiota is composed of a huge number of different bacteria, that produce a large
amount of compounds playing a key role in microbe selection and in the construction of a …

1H NMR-based metabolite profiling for biomarker identification

RA Silva, TCS Pereira, AR Souza, PR Ribeiro - Clinica Chimica Acta, 2020 - Elsevier
The metabolome is affected by individual physiologic and pathophysiologic states as well as
the environment. Metabolomics has become crucial approach for clinical studies, providing …

Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype

J Yang, N Shi, S Wang, M Wang, Y Huang, Y Wang… - Translational …, 2024 - Elsevier
To reveal dysregulated metabolism hallmark that was associated with a severe acute
pancreatitis (SAP) phenotype. In this study, LC-MS/MS-based targeted metabolomics was …

Quantitative metabolic analysis of plasma extracellular vesicles for the diagnosis of severe acute pancreatitis

D Lou, K Shi, HP Li, Q Zhu, L Hu, J Luo, R Yang… - Journal of …, 2022 - Springer
Background Severe acute pancreatitis (SAP) is the most common gastrointestinal disease
and is associated with unpredictable seizures and high mortality rates. Despite …

[HTML][HTML] Metabolomic-based clinical studies and murine models for acute pancreatitis disease: A review

Y Peng, J Hong, D Raftery, Q Xia, D Du - Biochimica et Biophysica Acta …, 2021 - Elsevier
Acute pancreatitis (AP) is one of the most common gastroenterological disorders requiring
hospitalization and is associated with substantial morbidity and mortality. Metabolomics …

Serum concentrations of citrate, tyrosine, 2-and 3-hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients

S Stryeck, M Gastrager, V Degoricija, M Trbušić… - Scientific reports, 2019 - nature.com
Considering the already established relationship between the extent of the metabolic
dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic …

Intestinal microflora and metabolites affect the progression of acute pancreatitis (AP)

Z Wang, M Guo, S Yang, Y Chen, J Cheng, Z Huang… - Gut Pathogens, 2024 - Springer
Specific intestinal metabolites are closely associated with the classification, severity, and
necrosis of acute pancreatitis (AP) and provide novel insights for in-depth clinical …

[HTML][HTML] NMR spectroscopy as a “green analytical method” in metabolomics and proteomics studies

KA Mielko, N Pudełko-Malik, A Tarczewska… - Sustainable Chemistry …, 2021 - Elsevier
Nuclear magnetic resonance (NMR) is one of two methods (in addition to MS) that
predominate in metabolomics and structural analysis. Due to the great demand for this type …

Plasmatic oxidative and metabonomic profile of patients with different degrees of biliary acute pancreatitis severity

P Silva-Vaz, I Jarak, L Rato, PF Oliveira… - Antioxidants, 2021 - mdpi.com
Acute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement
of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of …

Identification of potential diagnostic biomarkers of acute pancreatitis by serum metabolomic profiles

H Xiao, J Huang, X Zhang, R Ahmed, Q Xie, B Li, Y Zhu… - Pancreatology, 2017 - Elsevier
Acute pancreatitis (AP) is defined as an acute inflammation of pancreas that may cause
damage to other tissues and organs depending upon the severity of symptoms. The …