Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell
activation pathways involved in physiological immune responses against specific antigens …

Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface
of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor …

Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …

Despite recent advances in colorectal cancer (CRC) treatment, a large proportion of patients
show limited responses to therapies, especially in advanced stages. There is an urgent …

Background Onco-immunogenic molecule CD155 is overexpressed in various tumor
microenvironments (TME) including in colorectal cancer (CRC). Tumor-associated …

Tumour microenvironment (TME) is crucial to tumorigenesis. This study aimed to uncover
the differences in immune phenotypes of TME in endometrial cancer (EC) using Uterine …

Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The colonic
mucosa constitutes a critical barrier and a major site of immune regulation. The immune …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …