Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

The recent dramatic rise in obesity rates is an alarming global health trend that consumes an
ever increasing portion of health care budgets in Western countries. The root cause of …

Nutrition has long been considered more the domain of medicine and agriculture than of the
biological sciences, yet it touches and shapes all aspects of the natural world. The need for …

Context Energy balance is critical for survival and health, and control of food intake is an
integral part of this process. This report reviews hormonal signals that influence food intake …

Cell proliferation and neuroinflammation in the adult hypothalamus may contribute to the
pathogenesis of obesity. We tested whether the intertwining of these two processes plays a …

Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia. The
altered glucose homeostasis is caused by faulty signal transduction via the insulin signaling …

Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion
and metabolic functions of various cells. Depending on cell types, rates of glycolysis are …

BACKGROUND. Excessive insulin secretion may lead to glucose dysregulation. Our aim
was to identify primary (independent of insulin resistance) insulin hypersecretion in subjects …

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that operates as
sensor of cellular energy status and effector for its coupling to cell growth and proliferation …

Obesity is an emerging problem worldwide. Hospitalized obese patients often have a worse
outcome than patients of normal weight, particularly in the setting of trauma and critical care …