The Na+/I Symporter (NIS): Mechanism and Medical Impact

C Portulano, M Paroder-Belenitsky… - Endocrine …, 2014 - academic.oup.com
Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Immune cells as tumor drug delivery vehicles

F Combes, E Meyer, NN Sanders - Journal of controlled release, 2020 - Elsevier
This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …

The immunoimaging toolbox

AT Mayer, SS Gambhir - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …

The sodium iodide symporter (NIS) as an imaging reporter for gene, viral, and cell-based therapies

AR Penheiter, SJ Russell, SK Carlson - Current gene therapy, 2012 - ingentaconnect.com
Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells

N Emami-Shahri, J Foster, R Kashani… - Nature …, 2018 - nature.com
The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of
CD19+ B-cell malignancy has established a new therapeutic pillar of hematology–oncology …

[HTML][HTML] Radionuclide-based molecular imaging allows CAR-T cellular visualization and therapeutic monitoring

F Shao, Y Long, H Ji, D Jiang, P Lei, X Lan - Theranostics, 2021 - ncbi.nlm.nih.gov
Chimeric antigen receptor T cell (CAR-T) therapy is a new and effective form of adoptive cell
therapy that is rapidly entering the mainstream for the treatment of CD19-positive …

[HTML][HTML] Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back

BC Ahn - Theranostics, 2012 - ncbi.nlm.nih.gov
Molecular imaging, defined as the visual representation, characterization and quantification
of biological processes at the cellular and subcellular levels within intact living organisms …

[HTML][HTML] Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

HW Lee, P Gangadaran, S Kalimuthu… - BioMed research …, 2016 - hindawi.com
Tracking of immune cells in vivo is a crucial tool for development and optimization of cell-
based therapy. Techniques for tracking immune cells have been applied widely for …

18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET

T Watabe, H Ikeda, S Nagamori… - European journal of …, 2017 - Springer
Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18 F-
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …

Reporter genes for brain imaging using MRI, SPECT and PET

T Gao, P Wang, T Gong, Y Zhou, A Wang… - International Journal of …, 2022 - mdpi.com
The use of molecular imaging technologies for brain imaging can not only play an important
supporting role in disease diagnosis and treatment but can also be used to deeply study …