Single nucleotide polymorphisms (SNPs): functional implications of regulatory-SNP (rSNP) and structural RNA (srSNPs) in complex diseases

J Ramírez-Bello, G Vargas-Alarcón… - Gaceta medica de …, 2013 - medigraphic.com
Single nucleotide polymorphisms (SNPs) represent to the genetics variant most common
founded in the human genome. These polymorphisms have a wide distribution and can …

Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock

N Kothari, J Bogra, H Abbas, M Kohli, A Malik… - Cytokine, 2013 - Elsevier
INTRODUCTION: Systemic sepsis releases several cytokines among which tumor necrosis
factor alfa (TNFα) has emerged as key cytokine causing septic shock. Single Nucleotide …

Novel approaches and challenges to treatment of central nervous system viral infections

A Nath, KL Tyler - Annals of neurology, 2013 - Wiley Online Library
Existing and emerging viral central nervous system (CNS) infections are major sources of
human morbidity and mortality. Treatments of proven efficacy are currently limited …

The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case–control study

M Jafari, MR Nasiri, R Sanaei, S Anoosheh… - Infection, Genetics and …, 2016 - Elsevier
The innate immune response drives early events in Mycobacterium tuberculosis infection.
Since human genetic variation is an important determinant in the outcome of infection with …

[PDF][PDF] Polimorfismos de un solo nucleótido (SNP): implicaciones funcionales de los SNP reguladores (rSNP) y de los SNP-ARN estructurales (srSNP) en …

J Ramírez-Bello, G Vargas-Alarcón… - Gaceta medica de …, 2013 - anmm.org.mx
Los polimorfismos de un solo nucleótido (SNP) representan a las variantes genéticas más
comúnmente encontradas en el genoma humano. Debido a su amplia distribución, estos …

Tumour necrosis factor-alpha and nuclear factor-kappa B gene variants in sepsis

L Acar, N Atalan, EH Karagedik, A Ergen - Balkan Medical Journal, 2018 - dergipark.org.tr
Background: The humoral system is activated and various cytokines are released due to
infections in tissues and traumatic damage. Nuclear factor-kappa B dimers are encoded by …

TNF-α haplotype association with polycystic ovary syndrome–a South Indian study

MLN Deepika, KR Reddy, A Yashwanth… - Journal of assisted …, 2013 - Springer
Abstract Background Tumor Necrosis Factor Alpha (TNF-α), is a proinflammatory cytokine in
the pathogenesis of Polycystic Ovary Syndrome (PCOS). In order to investigate the role of …

Toll-like receptor-3 gene polymorphism in patients with Japanese encephalitis

S Biyani, RK Garg, A Jain, HS Malhotra… - Journal of …, 2015 - Elsevier
Introduction Japanese encephalitis (JE) is one of the most lethal mosquito-borne viral
encephalitis seen in India. Toll-like receptors (TLRs) play a critical role in host defence …

Potential Value of TNF-α (–376 G/A) Polymorphism and Cystatin C (CysC) in the Diagnosis of Sepsis Associated Acute Kidney Injury (S-AK I) and Prediction of …

HS Al-Amodi, S Abdelsattar, ZA Kasemy… - Frontiers in Molecular …, 2021 - frontiersin.org
Sepsis Associated Kidney Injury represents a major health concern as it is frequently
associated with increased risk of mortality and morbidity. We aimed to evaluate the potential …

Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility

KML Sarges, F Póvoa da Costa, EF Santos… - Viruses, 2024 - mdpi.com
Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory
mediators in the development of cytokine storm syndrome (CSS). Single nucleotide …