The elevated susceptibility to diabetes in India: an evolutionary perspective

JCK Wells, E Pomeroy, SR Walimbe… - Frontiers in public …, 2016 - frontiersin.org
India has rapidly become a “diabetes capital” of the world, despite maintaining high rates of
under-nutrition. Indians develop diabetes at younger age and at lower body weights than …

The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes

SR Thorn, PJ Rozance, LD Brown… - Seminars in …, 2011 - thieme-connect.com
The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in
response to exposure to reduced nutrient supply. These adaptations provide survival value …

Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

CS Rashid, A Bansal, RA Simmons - Physiology, 2018 - journals.physiology.org
Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of
metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and …

The impact of IUGR on pancreatic islet development and β-cell function

BH Boehmer, SW Limesand… - Journal of …, 2017 - joe.bioscientifica.com
Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

Placenta-specific Slc38a2/SNAT2 knockdown causes fetal growth restriction in mice

OR Vaughan, K Maksym, E Silva, K Barentsen… - Clinical …, 2021 - portlandpress.com
Fetal growth restriction (FGR) is a complication of pregnancy that reduces birth weight,
markedly increases infant mortality and morbidity and is associated with later-life …

Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency

SW Limesand, PJ Rozance - The Journal of physiology, 2017 - Wiley Online Library
Placental insufficiency and intrauterine growth restriction (IUGR) of the fetus affects
approximately 8% of all pregnancies and is associated with short‐and long‐term …

[HTML][HTML] Perfluoroalkyl acid levels in first-time mothers in relation to offspring weight gain and growth

I Gyllenhammar, B Diderholm, J Gustafsson… - Environment …, 2018 - Elsevier
We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time of
delivery are associated with birth outcome and if early life exposure (in utero/nursing) is …

Nutrient sensor signaling pathways and cellular stress in fetal growth restriction

B Hart, E Morgan, EU Alejandro - Journal of molecular …, 2019 - jme.bioscientifica.com
Fetal growth restriction is one of the most common obstetrical complications resulting in
significant perinatal morbidity and mortality. The most frequent etiology of human singleton …

Arginine nutrition and fetal brown adipose tissue development in nutrient-restricted sheep

MC Satterfield, KA Dunlap, DH Keisler, FW Bazer… - Amino acids, 2013 - Springer
Intrauterine growth restriction is a significant problem worldwide, resulting in increased rates
of neonatal morbidity and mortality, as well as increased risks for metabolic and …

Early-life nutritional programming of type 2 diabetes: experimental and quasi-experimental evidence

AM Vaiserman - Nutrients, 2017 - mdpi.com
Consistent evidence from both experimental and human studies suggest that inadequate
nutrition in early life can contribute to risk of developing metabolic disorders including type 2 …