Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

From the first described AD case in 1901 to the current year 2022, understanding the
pathogenesis of Alzheimer's disease (AD) and dementia has undergone a long and tortuous …

Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-
related cognitive impairments, but the underlying mechanisms remain unclear. We recently …

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …

Diabetes-induced vascular disorder is considered one of the deadly risk factors among
diabetic patients that are caused by persistent hyperglycemia that eventually leads to …

20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure,
cerebral blood flow and neuronal death following ischemia. Numerous human genetic …

Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms
involved are not well understood. We previously discovered that hyperglycemia induced …

Cognitive impairment and dementia are significant health burdens worldwide. Aging,
hypertension, and diabetes are the primary risk factors for Alzheimer's disease and …

Diabetes, hypertension, and aging are major contributors to cardiovascular and chronic
kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors have become a …