Physical principles underlying the complex biology of intracellular phase transitions
JM Choi, AS Holehouse… - Annual review of …, 2020 - annualreviews.org
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …
have the hallmarks of intracellular phase transitions. This suggests that a common …
[HTML][HTML] Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates
Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation
of membraneless compartments in cells. This realization has motivated major efforts to …
of membraneless compartments in cells. This realization has motivated major efforts to …
Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …
distinct biomolecular condensates that form via phase separation coupled to percolation …
Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations
Biomolecular condensates form via coupled associative and segregative phase transitions
of multivalent associative macromolecules. Phase separation coupled to percolation is one …
of multivalent associative macromolecules. Phase separation coupled to percolation is one …
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
Various physics-and data-driven sequence-dependent protein coarse-grained models have
been developed to study biomolecular phase separation and elucidate the dominant …
been developed to study biomolecular phase separation and elucidate the dominant …
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that
determine their driving forces for phase separation. Here we uncover the physicochemical …
determine their driving forces for phase separation. Here we uncover the physicochemical …
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
Phase transitions of linear multivalent proteins control the reversible formation of many
intracellular membraneless bodies. Specific non-covalent crosslinks involving …
intracellular membraneless bodies. Specific non-covalent crosslinks involving …
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …
compartmentalize their function. Cells also concentrate molecules into phase-separated …
LASSI: A lattice model for simulating phase transitions of multivalent proteins
Many biomolecular condensates form via spontaneous phase transitions that are driven by
multivalent proteins. These molecules are biological instantiations of associative polymers …
multivalent proteins. These molecules are biological instantiations of associative polymers …