[HTML][HTML] Effects of exercise therapy on joint instability in patients with osteoarthritis of the knee: A systematic review

S Kawabata, K Murata, K Nakao, M Sonoo… - … and Cartilage Open, 2020 - Elsevier
Objective Abnormal load stress caused by joint instability has been reported to be one of the
factors responsible for the development of osteoarthritis (OA). However, few studies have …

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms …

X Du, R Fan, J Kong - Frontiers in Medicine, 2024 - frontiersin.org
Background Knee osteoarthritis (KOA) is a disease that significantly affects the quality of life
of patients, with a complex pathophysiology that includes degeneration of cartilage and …

Osteophytes and fracture calluses share developmental milestones and are diminished by unloading

AW Hsia, AJ Emami, FD Tarke… - Journal of …, 2018 - Wiley Online Library
Osteophytes are a typical radiographic finding during osteoarthritis (OA), but the
mechanisms leading to their formation are not well known. Comparatively, fracture calluses …

[HTML][HTML] Controlling joint instability after anterior cruciate ligament transection inhibits transforming growth factor-beta-mediated osteophyte formation

K Murata, T Kokubun, K Onitsuka, Y Oka, T Kano… - Osteoarthritis and …, 2019 - Elsevier
Objective Abnormal joint instability contributes to cartilage damage and osteophyte
formation. We investigated whether controlling joint instability inhibited chronic synovial …

Effects of controlling abnormal joint movement on expression of MMP13 and TIMP-1 in osteoarthritis

K Onitsuka, K Murata, T Kokubun, S Fujiwara… - Cartilage, 2020 - journals.sagepub.com
Objective Abnormal joint movement is associated with osteoarthritis (OA). Previous studies
using the controlling abnormal joint movement (CAJM) model of OA reported delayed …

Abnormal thyroid hormone receptor signaling in osteoarthritic osteoblasts regulates microangiogenesis in subchondral bone

L Li, M Li, Y Pang, J Wang, Y Wan, C Zhu, Z Yin - Life sciences, 2019 - Elsevier
Aims Previous study indicated that the increase of local bio-availability of 3′ 3′ 5-
triiodothyronine (T3) influenced osteoarthritis (OA) initiation. We aimed to investigate the role …

Treadmill exercise after controlled abnormal joint movement inhibits cartilage degeneration and synovitis

Y Oka, K Murata, K Ozone, T Kano, Y Minegishi… - Life, 2021 - mdpi.com
Cartilage degeneration is the main pathological component of knee osteoarthritis (OA), but
no effective treatment for its control exists. Although exercise can inhibit OA, the abnormal …

Impact of controlling abnormal joint movement on the effectiveness of subsequent exercise intervention in mouse models of early knee osteoarthritis

Y Oka, K Murata, T Kano, K Ozone, K Arakawa… - Cartilage, 2021 - journals.sagepub.com
Objective Moderate mechanical stress is necessary for preserving the cartilage. The
clinician empirically understands that prescribing only exercise will progress osteoarthritis …

Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes

GD Rabelo, A Vom Scheidt, F Klebig, H Hemmatian… - Scientific Reports, 2020 - nature.com
Osteophytes-bony outgrowths on joint structures-are found in healthy individuals but are
specifically present in late osteoarthritis (OA). Osteophyte development and function is not …

Long-term effects of non-weight bearing and immobilization after anterior cruciate ligament reconstruction on joint contracture formation in rats

A Kaneguchi, N Masuhara, R Okahara… - Connective Tissue …, 2024 - Taylor & Francis
Purpose Non-weight bearing improves and immobilization worsens contracture induced by
anterior cruciate ligament reconstruction (ACLR), but effect persistence after reloading and …