Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

Abstract Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr
phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most …

During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …

SUMMARY Protein phosphatase 2A (PP2A) enzymes can suppress tumors, but they are
often inactivated in human cancers overexpressing inhibitory proteins. Here, we identify a …

Phosphorylation as a post-translational modification is critical for cellular homeostasis.
Kinases and phosphatases regulate phosphorylation levels by adding or removing …

Progression through the cell cycle is controlled by regulated and abrupt changes in
phosphorylation. Mitotic entry is initiated by increased phosphorylation of mitotic proteins, a …

PP2A is an essential protein phosphatase that regulates most cellular processes through the
formation of holoenzymes containing distinct regulatory B‐subunits. Only a limited number of …

Here, we will review the evidence showing that mitotic exit is initiated by regulated
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …

The accurate segregation of genetic material to daughter cells during mitosis depends on
the precise coordination and regulation of hundreds of proteins by dynamic phosphorylation …

The separation of sister chromatids at anaphase, which is regulated by an E3 ubiquitin
ligase called the anaphase-promoting complex/cyclosome (APC/C), is arguably the most …