This review provides a comprehensive overview of our understanding of the role that
glycans play in the formation, loading and release of extracellular vesicles (EVs). The …

Introduction Breast cancer (BC) is the most common diagnosed cancer and the second
leading cause of cancer-associated death in women, with the triple negative (TNBC) …

Abstract Next-generation Trop-2–targeted therapy against advanced cancers is hampered
by expression of Trop-2 in normal tissues. We discovered that Trop-2 undergoes proteolytic …

Trop-2 is a highly conserved one-pass transmembrane mammalian glycoprotein that is
normally expressed in tissues such as the lung, intestines, and kidney during embryonic …

A phylogenetic conservation analysis of Trop-2 across vertebrate species showed a high
degree of sequence conservation, permitting to explore multiple models as pre-clinical …

Background: Trop2 (trophoblast cell-surface antigen 2) is overexpressed in multiple
malignancies and is closely associated with poor prognosis, thus positioning it as a …

Abstract Trophoblast antigen 2 (Trop2) is a transmembrane glycoprotein upregulated in
multiple solid tumours. Trop2-based passive immunotherapies are in clinical trials, while …

Cancer stem cells (CSCs), found within tumors, are powerful drivers of disease recurrence
and metastasis. Their abilities to self-renew and maintain stem-like properties make …

Recently, an anti-trophoblast surface antigen-2 (Trop-2) antibody-drug conjugate targeting
Trop-2 positive cancer cells has been approved for treating patients with unresectable …

Protein Trop2 was discovered more than 40 years ago due to its high expression on the
trophoblast surface. Later it was found out that Trop2 is overexpressed in most carcinomas …