Protein folding in the endoplasmic reticulum is an oxidative process that relies on protein
disulfide isomerase (PDI) and endoplasmic reticulum oxidase 1 (ERO1). Over 30% of …

Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …

Gliomas are the most common and lethal primary malignant tumor of the brain. Routine
treatment including surgical resection, chemotherapy, and radiotherapy produced limited …

Aseptic loosening caused by peri-implant osteolysis (PIO) is a common complication after
joint replacement, and there is still no better treatment than revision surgery. The wear …

Osteoclasts play a central role in cancer-cell-induced osteolysis, but the molecular
mechanisms of osteoclast activation during bone metastasis formation are incompletely …

The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many
transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear …

Due to the accumulation of reactive oxygen species (ROS) and heightened activity of
osteoclasts, postmenopausal osteoporosis could cause severe pathological bone …

Clasmatodendrosis is a kind of astroglial degeneration pattern which facilitates excessive
autophagy. Although abnormal mitochondrial elongation is relevant to this astroglial …

Chronic inflammation and infection in the tissue surrounding implants after total joint
replacement is closely associated with the innate immune response to surgical implants …

Phosphatase and tensin homolog (PTEN) is a critical regulator of tumorigenesis and bone
remodeling, which is also found expressed in the periodontal tissues. Periodontitis is one of …