Role of the ERO1-PDI interaction in oxidative protein folding and disease
Protein folding in the endoplasmic reticulum is an oxidative process that relies on protein
disulfide isomerase (PDI) and endoplasmic reticulum oxidase 1 (ERO1). Over 30% of …
disulfide isomerase (PDI) and endoplasmic reticulum oxidase 1 (ERO1). Over 30% of …
Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging
H Wang, T Yuan, Y Wang, C Liu, D Li, Z Li, S Sun - Aging Cell, 2024 - Wiley Online Library
Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …
aging population, and often leads to joint pain, disability, and a diminished quality of life …
PDIA5 is correlated with immune infiltration and predicts poor prognosis in gliomas
Gliomas are the most common and lethal primary malignant tumor of the brain. Routine
treatment including surgical resection, chemotherapy, and radiotherapy produced limited …
treatment including surgical resection, chemotherapy, and radiotherapy produced limited …
Autophagy inhibitors 3-MA and LY294002 repress osteoclastogenesis and titanium particle-stimulated osteolysis
W Chen, G Xian, M Gu, B Pan, X Wu, Y Ye… - Biomaterials …, 2021 - pubs.rsc.org
Aseptic loosening caused by peri-implant osteolysis (PIO) is a common complication after
joint replacement, and there is still no better treatment than revision surgery. The wear …
joint replacement, and there is still no better treatment than revision surgery. The wear …
[HTML][HTML] De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
LF Sandor, JB Huh, P Benko, T Hiraga, S Poliska… - Cell Reports, 2024 - cell.com
Osteoclasts play a central role in cancer-cell-induced osteolysis, but the molecular
mechanisms of osteoclast activation during bone metastasis formation are incompletely …
mechanisms of osteoclast activation during bone metastasis formation are incompletely …
Protein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies
EY Bakker, M Fujii… - International …, 2022 - spandidos-publications.com
The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many
transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear …
transcription factors including estrogen receptor α (ERα), nuclear factor (NF)‑κB, nuclear …
Inhibition of protein disulfide isomerase attenuates osteoclast differentiation and function via the readjustment of cellular redox state in postmenopausal osteoporosis
Y Wang, T Yuan, H Wang, Q Meng, H Li, C Feng, Z Li… - Inflammation, 2024 - Springer
Due to the accumulation of reactive oxygen species (ROS) and heightened activity of
osteoclasts, postmenopausal osteoporosis could cause severe pathological bone …
osteoclasts, postmenopausal osteoporosis could cause severe pathological bone …
CDDO-Me Abrogates Aberrant Mitochondrial Elongation in Clasmatodendritic Degeneration by Regulating NF-κB-PDI-Mediated S-Nitrosylation of DRP1
DS Lee, TH Kim, H Park, JE Kim - International Journal of Molecular …, 2023 - mdpi.com
Clasmatodendrosis is a kind of astroglial degeneration pattern which facilitates excessive
autophagy. Although abnormal mitochondrial elongation is relevant to this astroglial …
autophagy. Although abnormal mitochondrial elongation is relevant to this astroglial …
Titanium particles induce apoptosis by promoting autophagy in macrophages via the PI3K/Akt signaling pathway
Chronic inflammation and infection in the tissue surrounding implants after total joint
replacement is closely associated with the innate immune response to surgical implants …
replacement is closely associated with the innate immune response to surgical implants …
PTEN Inhibits Inflammatory Bone Loss in Ligature‐Induced Periodontitis via IL1 and TNF‐α
C Fu, Z Wei, D Zhang - BioMed research international, 2019 - Wiley Online Library
Phosphatase and tensin homolog (PTEN) is a critical regulator of tumorigenesis and bone
remodeling, which is also found expressed in the periodontal tissues. Periodontitis is one of …
remodeling, which is also found expressed in the periodontal tissues. Periodontitis is one of …