Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Problems arising during translation of mRNAs lead to ribosome stalling and collisions that
trigger a series of quality control events. However, the global cellular response to ribosome …

Messenger RNAs (mRNAs) encode information in both their primary sequence and their
higher order structure. The independent contributions of factors like codon usage and …

The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid
peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay)
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …