Detecting the ultra-low abundance of analytes in real-life samples, such as biological fluids,
water, soil, and food, requires the design and development of high-performance biosensing …

Covalent inhibition has become more accepted in the past two decades, as illustrated by the
clinical approval of several irreversible inhibitors designed to covalently modify their target …

During DNA replication, the deubiquitinating enzyme USP1 limits the recruitment of
translesion polymerases by removing ubiquitin marks from PCNA to allow specific regulation …

Protein ubiquitination is a key post-translational modification regulating a wide range of
biological processes. Ubiquitination involves the covalent attachment of the small protein …

TRIM family of E3 ubiquitin ligases have an amino-terminal conserved tripartite motif
consisting of RING, B-Box, coiled-coil domain and different C-terminal domain leading it to …

Deubiquitinating enzymes cleave ubiquitin (Ub) from its attachment to another Ub, other
proteins, peptides, or non-peptide adducts. In all cases, substrate hydrolysis by DUBs …

Previous studies have identified Cockayne Syndrome B (CSB) as a helicase that can
resolve non-canonical DNA structures, called G-quadruplexes (G4s). The aim of this study is …

Covalent inhibition has become more accepted in the past two decades, as illustrated by the
clinical approval of several irreversible inhibitors designed to covalently modify their target …

Covalent inhibition has become more accepted in the past two decades, as illustrated by the
clinical approval of several irreversible inhibitors designed to covalently modify their target …