Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …
bipolar disorders and other psychotic disorders. However, they might cause metabolic …
Differential regulation of GPCRs—are GRK expression levels the key?
ESF Matthees, RS Haider, C Hoffmann… - Frontiers in Cell and …, 2021 - frontiersin.org
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders
R Juza, K Musilek, E Mezeiova… - Medicinal Research …, 2023 - Wiley Online Library
Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …
Allosteric regulation of G-protein-coupled receptors: from diversity of molecular mechanisms to multiple allosteric sites and their ligands
AO Shpakov - International Journal of Molecular Sciences, 2023 - mdpi.com
Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …
Structure, function and drug discovery of GPCR signaling
L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …
array of physiological processes and responses, such as sensory perception (eg, vision …
Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism
DM Perez - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …
Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review
C Brasso, G Colli, R Sgro, S Bellino, P Bozzatello… - Biomedicines, 2023 - mdpi.com
Schizophrenia is among the fifteen most disabling diseases worldwide. Negative symptoms
(NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the …
(NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the …
Allosteric antagonism of the pregnane X receptor (PXR): current-state-of-the-art and prediction of novel allosteric sites
R Kamaraj, M Drastik, J Maixnerova, P Pavek - Cells, 2022 - mdpi.com
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds
A Waldbillig, M Baranova, S Neumann… - Frontiers in Fungal …, 2023 - frontiersin.org
Psilocybe mushrooms, otherwise known as “magic” mushrooms, owe their psychedelic
effect to psilocin, a serotonin subtype 2A (5-HT2A) receptor agonist and metabolite of …
effect to psilocin, a serotonin subtype 2A (5-HT2A) receptor agonist and metabolite of …
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey
L Brunetti, F Francavilla, M Leopoldo, E Lacivita - Pharmaceuticals, 2024 - mdpi.com
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter regulating numerous
physiological functions, and its dysregulation is a crucial component of the pathological …
physiological functions, and its dysregulation is a crucial component of the pathological …