Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

Schizophrenia is among the fifteen most disabling diseases worldwide. Negative symptoms
(NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the …

The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with
high levels of expression in the liver. It not only plays a key role in drug metabolism and …

Psilocybe mushrooms, otherwise known as “magic” mushrooms, owe their psychedelic
effect to psilocin, a serotonin subtype 2A (5-HT2A) receptor agonist and metabolite of …

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter regulating numerous
physiological functions, and its dysregulation is a crucial component of the pathological …