Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

[HTML][HTML] Dietary lipids, gut microbiota and lipid metabolism

M Schoeler, R Caesar - Reviews in endocrine and metabolic disorders, 2019 - Springer
The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

[HTML][HTML] The cross-talk between gut microbiota and lungs in common lung diseases

D Zhang, S Li, N Wang, HY Tan, Z Zhang… - Frontiers in …, 2020 - frontiersin.org
Emerging findings indicate there is a vital cross-talk between gut microbiota and the lungs,
which is known as gut–lung axis. The gut disturbances in lung diseases including allergy …

Dietary metabolism, the gut microbiome, and heart failure

WHW Tang, DY Li, SL Hazen - Nature Reviews Cardiology, 2019 - nature.com
Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

[HTML][HTML] Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

[HTML][HTML] Trimethylamine N-oxide (TMAO) in human health

P Gatarek, J Kaluzna-Czaplinska - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and
diseases, this topic is very popular and is often taken up by researchers. TMAO is a low …

[HTML][HTML] The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions

M Trøseid, GØ Andersen, K Broch, JR Hov - EBioMedicine, 2020 - thelancet.com
Host-microbiota interactions involving inflammatory and metabolic pathways have been
linked to the pathogenesis of multiple immune-mediated diseases and metabolic conditions …

Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review

WHW Tang, F Bäckhed, U Landmesser… - Journal of the American …, 2019 - jacc.org
Despite major strides in reducing cardiovascular disease (CVD) burden with modification of
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …

[HTML][HTML] Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk

W Zhu, JC Gregory, E Org, JA Buffa, N Gupta, Z Wang… - Cell, 2016 - cell.com
Normal platelet function is critical to blood hemostasis and maintenance of a closed
circulatory system. Heightened platelet reactivity, however, is associated with …

[HTML][HTML] Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis

Z Wang, AB Roberts, JA Buffa, BS Levison, W Zhu… - Cell, 2015 - cell.com
Summary Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite,
both enhances atherosclerosis in animal models and is associated with cardiovascular risks …