Background Sorbin and SH3 domain containing 2 (Sorbs2) protein is a cytoskeletal adaptor
with an emerging role in cardiac biology and disease; yet, its potential relevance to adult …

The functioning of the human heart relies on complex electrical and communication systems
that coordinate cardiac contractions and sustain rhythmicity. One of the key players …

BACKGROUND: Vascular large conductance Ca2+-activated K+ (BK) channel, composed of
the α-subunit (BK-α) and the β1-subunit (BK-β1), is a key determinant of coronary …

The voltage-gated K+ channel plays a key role in atrial excitability, conducting the ultra-rapid
rectifier K+ current (IKur) and contributing to the repolarization of the atrial action potential. In …

Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it
remains one of the most aggressive and deadly tumor of the central nervous system (CNS) …

The canonical transient receptor potential 6 gene, TRPC6, has been implicated as a putative
risk gene for chemotherapy-induced congestive heart failure, but knowledge of specific risk …

Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac disorder characterized by the
gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to …

Atrial fibrillation (AF) is one of the most common arrhythmias in medical practice. Diabetes
mellitus (DM) is one of the independent risk factors for atrial fibrillation. The increased …

Background To study the problem of male sterility of cattle-yak and improve the yak
crossbreeding, this study obtained the testicular Sertoli cells of yak and cattle-yak and …

Rationale Sorbs2 is a cardiomyocyte-enriched, cytoskeletal adaptor protein, and given some
evidence for its dysregulated expression in failing hearts, there is growing interest in …