Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

In recent decades, drugs used to treat malaria infection have been shown to be beneficial for
many other diseases, including viral infections. In particular, they have received special …

Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic
(liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Malaria, a parasite vector-borne disease, is one of the greatest health threats in tropical
regions, despite the availability of malaria chemoprophylaxis. The emergence and rapid …

Controlling the spread of antimalarial drug resistance, especially resistance of P lasmodium
falciparum to artemisinin‐based combination therapies, is a high priority. Available data …

The combination of piperaquine and dihydroartemisinin has recently become the official first-
line therapy in several Southeast Asian countries. The pharmacokinetic mismatching of …

Membrane transport proteins, also known as transporters, control the movement of ions,
nutrients, metabolites, and waste products across the membranes of a cell and are central to …

The phylum Apicomplexa includes obligate intracellular parasites that cause both benign
and serious diseases. Human infection by Toxoplasma gondii can be asymptomatic but can …

Abstract Background The emergence of Plasmodium falciparum resistance to most anti-
malarial compounds has highlighted the urgency to develop new drugs and to clarify the …