Viral RNA replication and transcription involves not only viral RNA-dependent RNA
polymerases, but also cellular proteins, the majority of which are subverted from the RNA …

Respiratory syncytial virus is the major respiratory pathogen of infants and children
worldwide, with no effective treatment or vaccine available. Steady progress has been made …

After interaction of human immunodeficiency virus type 1 (HIV-1) virions with cell surface
receptors, a series of poorly characterized events results in establishment of a viral reverse …

Efficient transcription and replication of the influenza virus genome are dependent upon host-
derived factors. Using an in vitro RNA synthesis system, we have purified and identified …

Little is known about the functions of the matrix (M) protein of respiratory syncytial virus
(RSV). By analogy with other negative-strand RNA viruses, the M protein should inhibit the …

Components of paramyxoviruses are assembled at the plasma membrane of infected cells,
and progeny viruses are formed by the budding process. Although the molecular …

Background While our battle with the COVID-19 pandemic continues, a multitude of Omics
data have been generated from patient samples in various studies. Translation of these data …

It is just over 20 years since the landmark discovery was made by Baltimore et al.(1970) that
vesicular stomatitis virus (VSV) packages within the mature virion the vital RNA-dependent …

Viruses succeed as intracellular parasites because of their ability to invade cells and
appropriate the cellular machinery required during their life cycle. The actin cytoskeleton of …

Biopharmaceuticals are of increasing importance in the treatment of a variety of diseases. A
remaining concern associated with their production is the potential introduction of …