Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong
prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a …

Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial
in signal transduction and regulation of various cell biological processes, such as …

Objective Diabetic cardiomyopathy (DCM) is a serious complication of diabetes, but its
pathogenesis is still unclear. This study investigated the mechanism of long noncoding RNA …

Apoptosis of endothelial cells (ECs) is an early pathogenic event in various fibrotic diseases.
In this study, we evaluated whether paracrine mediators produced by apoptotic ECs play …

Cardiac fibroblasts (CF) are crucial in left ventricular (LV) healing and remodeling after
myocardial infarction (MI). They are typically activated into myofibroblasts that express alpha …

Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis.
However, their function remains limited in silicosis. Here, we observed that miR-125a-3p …

Extracellular signal‐regulated kinase 1 (ERK1) is a critical part of the mitogen‐activated
protein kinase signal transduction pathway, which is involved in hepatic fibrosis. However …

Objective. Systemic sclerosis (SSc) is a systemic connective tissue disease of unknown
etiology. Aberrant gene expression and epigenetic modifications in circulating immune cells …

Abstract Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has
been proposed for cancer immunotherapy, its intratumoral expression may be correlated …

Aged mice in a murine model of myocardial infarction exhibit less effective myocardial
repair. We hypothesized that the deficiency arises from altered lineage choice of …