Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Tumor cells rewire metabolic pathways to adapt to their increased nutritional demands for
energy, reducing equivalents, and cellular biosynthesis. Alternations in amino acid …

Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid
leukemia (AML) have made enormous progress during the past decades. Because AML is a …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

Acute myeloid leukemia (AML) is one of the most common and life-threatening leukemias. A
highly diverse and flexible metabolism contributes to the aggressiveness of the disease that …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Highlights•Reviewed the function of arginine and its metabolites in arginine deprivation
therapy.•Discussed the difference of arginine deiminase and recombinant human arginase …

Hematological and solid cancers catabolize the semiessential amino acid arginine to drive
cell proliferation. However, the resulting low arginine microenvironment also impairs …

Cancer is caused by uncontrollable growth of neoplastic cells, leading to invasion of
adjacent and distant tissues resulting in death. Cancer cells have specific nutrient (s) …