[HTML][HTML] Recent progress of magnetically actuated DNA micro/nanorobots

F Liu, X Liu, Q Huang, T Arai - Cyborg and Bionic Systems, 2022 - spj.science.org
In the past few decades, the field of DNA origami-based micro/nanotechnology has
developed dramatically and spawned attention increasingly, as its high integrality, rigid …

[HTML][HTML] A guide to magnetic tweezers and their applications

R Sarkar, VV Rybenkov - Frontiers in Physics, 2016 - frontiersin.org
Magnetic force spectroscopy is a rapidly developing single molecule technique that has
found numerous applications at the interface of physics and biology. Since the invention of …

Molecular force spectroscopy with a DNA origami–based nanoscopic force clamp

PC Nickels, B Wünsch, P Holzmeister, W Bae… - Science, 2016 - science.org
Forces in biological systems are typically investigated at the single-molecule level with
atomic force microscopy or optical and magnetic tweezers, but these techniques suffer from …

Single-molecule analysis and engineering of DNA motors

S Mohapatra, CT Lin, XA Feng, A Basu, T Ha - Chemical reviews, 2019 - ACS Publications
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

Ephemeral states in protein folding under force captured with a magnetic tweezers design

R Tapia-Rojo, EC Eckels… - Proceedings of the …, 2019 - National Acad Sciences
Magnetic tape heads are ubiquitously used to read and record on magnetic tapes in
technologies as diverse as old VHS tapes, modern hard-drive disks, or magnetic bands on …

Probing the mechanical properties, conformational changes, and interactions of nucleic acids with magnetic tweezers

F Kriegel, N Ermann, J Lipfert - Journal of structural biology, 2017 - Elsevier
Nucleic acids are central to the storage and transmission of genetic information. Mechanical
properties, along with their sequence, both enable and fundamentally constrain the …

Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales

R Tapia-Rojo, M Mora, S Garcia-Manyes - Nature Protocols, 2024 - nature.com
The reversible unfolding and refolding of proteins is a regulatory mechanism of tissue
elasticity and signalling used by cells to sense and adapt to extracellular and intracellular …

Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines

JS Lewis, AM van Oijen, LM Spenkelink - Chemical Reviews, 2023 - ACS Publications
The paradigm of cellular systems as deterministic machines has long guided our
understanding of biology. Advancements in technology and methodology, however, have …

Facile assembly/disassembly of DNA nanostructures anchored on cell-mimicking giant vesicles

R Peng, H Wang, Y Lyu, L Xu, H Liu… - Journal of the …, 2017 - ACS Publications
DNA nanostructures assembled on living cell membranes have become powerful research
tools. Synthetic lipid membranes have been used as a membrane model to study the …

[HTML][HTML] Dynamic interplay between target search and recognition for a Type I CRISPR-Cas system

P Aldag, M Rutkauskas, J Madariaga-Marcos… - Nature …, 2023 - nature.com
CRISPR-Cas effector complexes enable the defense against foreign nucleic acids and have
recently been exploited as molecular tools for precise genome editing at a target locus. To …