N-Acetylcysteine: Antioxidant, Aldehyde Scavenger, and More
A Zhitkovich - Chemical research in toxicology, 2019 - ACS Publications
N-Acetylcysteine is a commonly used antioxidant that is broadly effective despite its limited
reactive oxygen species (ROS) reactivity. Chemoprotection by N-acetylcysteine frequently …
reactive oxygen species (ROS) reactivity. Chemoprotection by N-acetylcysteine frequently …
Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature
AC Zavala-Valencia, L Velasco-Hidalgo… - … : Targets and Therapy, 2024 - Taylor & Francis
N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing
the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus …
the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus …
Antioxidative effects of N‐acetylcysteine in patients with β–thalassemia: A quick review on clinical trials
M Ghazaiean, A Aliasgharian, H Karami… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aims Several studies have highlighted the potent antioxidant
properties of N‐acetyl cysteine (NAC). This review aimed to assess the impact of NAC on …
properties of N‐acetyl cysteine (NAC). This review aimed to assess the impact of NAC on …
The scavenging capacity of γ-aminobutyric acid for acrolein and the cytotoxicity of the formed adduct
Acrolein is a notorious aldehyde with hazardous impacts on humans. γ-Aminobutyric acid
(GABA) is a functional amino acid present widely in foods. This study aimed at investigating …
(GABA) is a functional amino acid present widely in foods. This study aimed at investigating …
Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling
A Morimoto, N Takasugi, Y Pan, S Kubota… - Journal of Biological …, 2024 - ASBMB
Reactive carbonyl species (RCS), which are abundant in the environment and are produced
in vivo under stress, covalently bind to nucleophilic residues such as cysteine (Cys) in …
in vivo under stress, covalently bind to nucleophilic residues such as cysteine (Cys) in …
[HTML][HTML] Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism
Background Retrospective studies revealed that cigarette smoking enhances risk of
incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in …
incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in …
Complex coronary instent chronic total occlusion lesions: oxidative stress, inflammation, and coronary stent lengths
X Li, D Guo, Y Chen, Y Hu… - Oxidative Medicine and …, 2021 - Wiley Online Library
The oxidative stress and inflammation played the key roles in the development of
atherosclerotic coronary plaques. However, the relationships between pro/antioxidant …
atherosclerotic coronary plaques. However, the relationships between pro/antioxidant …
[HTML][HTML] Cystine transporter SLC7A11 regulates sensitivity to unsaturated carbonyl compounds in mouse macrophage cell lines
T Higashi, K Hashimoto, Y Mai, F Naganuma… - Journal of …, 2024 - Elsevier
Cytotoxic effects of cigarette smoke are thought to be causes of cigarette smoking-related
diseases such as respiratory infection, chronic obstructive pulmonary disease, and …
diseases such as respiratory infection, chronic obstructive pulmonary disease, and …
Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D
R Takamiya, M Takahashi, T Maeno, A Saito… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Abstract Background Surfactant proteins (SP) A and D belong to collectin family proteins,
which play important roles in innate immune response in the lung. We previously …
which play important roles in innate immune response in the lung. We previously …
Metabolic fate of the natural anticancer agent cucurbitacin B: an LC–MS/MS-enabled profiling of its major phase I and II conjugates in vivo
WY Liu, D Xu, HH Meng, CY Wang, X Feng… - Analytical and …, 2024 - Springer
Cucurbitacin B (CuB) is a natural triterpenoid with diverse pharmacological effects including
potent anticancer activity. However, its oral bioavailability is hampered by limited …
potent anticancer activity. However, its oral bioavailability is hampered by limited …