N-Acetylcysteine: Antioxidant, Aldehyde Scavenger, and More

A Zhitkovich - Chemical research in toxicology, 2019 - ACS Publications
N-Acetylcysteine is a commonly used antioxidant that is broadly effective despite its limited
reactive oxygen species (ROS) reactivity. Chemoprotection by N-acetylcysteine frequently …

Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature

AC Zavala-Valencia, L Velasco-Hidalgo… - … : Targets and Therapy, 2024 - Taylor & Francis
N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing
the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus …

Antioxidative effects of N‐acetylcysteine in patients with β–thalassemia: A quick review on clinical trials

M Ghazaiean, A Aliasgharian, H Karami… - Health Science …, 2024 - Wiley Online Library
Abstract Background and Aims Several studies have highlighted the potent antioxidant
properties of N‐acetyl cysteine (NAC). This review aimed to assess the impact of NAC on …

The scavenging capacity of γ-aminobutyric acid for acrolein and the cytotoxicity of the formed adduct

K Jiang, Z Yin, P Zhou, H Guo, C Huang, G Zhang… - Food & function, 2020 - pubs.rsc.org
Acrolein is a notorious aldehyde with hazardous impacts on humans. γ-Aminobutyric acid
(GABA) is a functional amino acid present widely in foods. This study aimed at investigating …

Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling

A Morimoto, N Takasugi, Y Pan, S Kubota… - Journal of Biological …, 2024 - ASBMB
Reactive carbonyl species (RCS), which are abundant in the environment and are produced
in vivo under stress, covalently bind to nucleophilic residues such as cysteine (Cys) in …

[HTML][HTML] Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism

V Gunda, YS Chhonker, NS Natesh, P Raut… - Biomedicine & …, 2021 - Elsevier
Background Retrospective studies revealed that cigarette smoking enhances risk of
incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in …

Complex coronary instent chronic total occlusion lesions: oxidative stress, inflammation, and coronary stent lengths

X Li, D Guo, Y Chen, Y Hu… - Oxidative Medicine and …, 2021 - Wiley Online Library
The oxidative stress and inflammation played the key roles in the development of
atherosclerotic coronary plaques. However, the relationships between pro/antioxidant …

[HTML][HTML] Cystine transporter SLC7A11 regulates sensitivity to unsaturated carbonyl compounds in mouse macrophage cell lines

T Higashi, K Hashimoto, Y Mai, F Naganuma… - Journal of …, 2024 - Elsevier
Cytotoxic effects of cigarette smoke are thought to be causes of cigarette smoking-related
diseases such as respiratory infection, chronic obstructive pulmonary disease, and …

Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D

R Takamiya, M Takahashi, T Maeno, A Saito… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Abstract Background Surfactant proteins (SP) A and D belong to collectin family proteins,
which play important roles in innate immune response in the lung. We previously …

Metabolic fate of the natural anticancer agent cucurbitacin B: an LC–MS/MS-enabled profiling of its major phase I and II conjugates in vivo

WY Liu, D Xu, HH Meng, CY Wang, X Feng… - Analytical and …, 2024 - Springer
Cucurbitacin B (CuB) is a natural triterpenoid with diverse pharmacological effects including
potent anticancer activity. However, its oral bioavailability is hampered by limited …