[HTML][HTML] DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma
Epigenetic alterations have been identified as a major characteristic in human cancers.
Advances in the field of epigenetics have contributed significantly in refining our knowledge …
Advances in the field of epigenetics have contributed significantly in refining our knowledge …
Epigenetic therapy as a novel approach in hepatocellular carcinoma
I Anestopoulos, GP Voulgaridou… - Pharmacology & …, 2015 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of liver malignancy and one with
high fatality. Its 5-year survival rate remains low and thus, there is a need for improvement of …
high fatality. Its 5-year survival rate remains low and thus, there is a need for improvement of …
Genome-wide profiles of extra-cranial malignant rhabdoid tumors reveal heterogeneity and dysregulated developmental pathways
Malignant rhabdoid tumors (MRTs) are rare lethal tumors of childhood that most commonly
occur in the kidney and brain. MRTs are driven by SMARCB1 loss, but the molecular …
occur in the kidney and brain. MRTs are driven by SMARCB1 loss, but the molecular …
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1
Colorectal cancer remains the most prevalent malignancy in humans. The impact of
epigenetic alterations on the development of this complex disease is now being recognized …
epigenetic alterations on the development of this complex disease is now being recognized …
Comprehensive DNA methylation analysis of benign and malignant adrenocortical tumors
AL Fonseca, J Kugelberg, LF Starker… - Genes …, 2012 - Wiley Online Library
The molecular pathogenesis of benign and malignant adrenocortical tumors (ACT) is
incompletely clarified. The role of DNA methylation in adrenocortical tumorigenesis has not …
incompletely clarified. The role of DNA methylation in adrenocortical tumorigenesis has not …
[HTML][HTML] Rapid quantification of DNA methylation by measuring relative peak heights in direct bisulfite-PCR sequencing traces
Various technologies are currently available to quantify DNA methylation. However, rapid
and simple methods for determining the DNA methylation status of CpG sites in genes still …
and simple methods for determining the DNA methylation status of CpG sites in genes still …
Lipid–polymer nanoparticles encapsulating doxorubicin and 2′-deoxy-5-azacytidine enhance the sensitivity of cancer cells to chemical therapeutics
Nanomedcine holds great potential in cancer therapy due to its flexibility on drug delivery,
protection, releasing, and targeting. Epigenetic drugs, such as 2′-deoxy-5-azacytidine …
protection, releasing, and targeting. Epigenetic drugs, such as 2′-deoxy-5-azacytidine …
Phospholipase C delta 1 is a novel 3p22. 3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric …
XT Hu, FB Zhang, YC Fan, XS Shu, AHY Wong… - Oncogene, 2009 - nature.com
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that
mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular …
mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular …
Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma
Background With the development of high-throughput screening, a variety of genetic
alterations has been found in hepatocellular carcinoma (HCC). Although previous studies …
alterations has been found in hepatocellular carcinoma (HCC). Although previous studies …
Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma
CJ Ricketts, MR Morris, D Gentle, M Brown, N Wake… - Epigenetics, 2012 - Taylor & Francis
In order to identify novel candidate tumor suppressor genes (TSGs) implicated in renal cell
carcinoma (RCC), we performed genome-wide methylation profiling of RCC using the …
carcinoma (RCC), we performed genome-wide methylation profiling of RCC using the …