Research models of sulfur mustard-and nitrogen mustard-induced ocular injuries and potential therapeutics

N Mishra, R Agarwal - Experimental eye research, 2022 - Elsevier
Sulfur mustard (SM) is a notorious, bifunctional alkylating vesicant that was first used in
warfare during World War I in 1917 and since then has been deployed in numerous …

Advances in sulfur mustard-induced DNA adducts: Characterization and detection

X Cheng, C Liu, Y Yang, L Liang, B Chen, H Yu, J Xia… - Toxicology letters, 2021 - Elsevier
Sulfur mustard (SM) is a blister chemical warfare agent with severe cytotoxicity and
genotoxicity. It can extensively alkylate important macromolecules in organisms, such as …

MiR-146a-5p delivered by hucMSC extracellular vesicles modulates the inflammatory response to sulfur mustard-induced acute lung injury

Z Pei, J Cen, X Zhang, C Gong, M Sun, W Meng… - Stem Cell Research & …, 2023 - Springer
Background Sulfur mustard (SM) is a highly toxic chemical warfare agent that has caused
numerous casualties during wars and conflicts in the past century. Specific antidotes or …

Terrorist attacks in the Middle East: a counter-terrorism medicine analysis

D Tin, S Fares, M Al Mulhim… - Prehospital and disaster …, 2022 - cambridge.org
Background: The Middle East and North Africa (MENA) region has been, like many parts of
the world, a hotbed for terrorist activities. Terrorist attacks can affect both demand for and …

[HTML][HTML] Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices

A Bellomo, J Herbert, MJ Kudlak, JD Laskin… - Toxicology and Applied …, 2024 - Elsevier
Nitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung
injury which can progress to chronic disease. Due to the complex nature of NM injury, it has …

Evidence for the systemic diffusion of (2-chloroethyl)-ethyl-sulfide, a sulfur mustard analog, and its deleterious effects in brain

M Gilardoni, D Léonço, F Caffin, F Gros-Désormeaux… - Toxicology, 2021 - Elsevier
Sulfur mustard, a chemical warfare agent known to be a vesicant of skin, readily diffuses in
the blood stream and reaches internal organs. In the present study, we used the analog (2 …

Supporting discovery and development of medical countermeasures for chemical injury to eye and skin

H Araj, H Tseng, DT Yeung - Experimental eye research, 2022 - Elsevier
Vesicants, from vesica (Latin for blister), can cause local and systemic toxicity. They include
the chemotherapy drug nitrogen mustard and chemical warfare agents sulfur mustard …

Bent‐But‐Not‐Broken: Reactive Metal‐Organic Framework Composites from Elastomeric Phase‐Inverted Polymers

GW Peterson, JJ Mahle, TM Tovar… - Advanced Functional …, 2020 - Wiley Online Library
A phase inversion process is used to fabricate composite beads from the metal–organic
framework (MOF) UiO‐66‐NH2 and the elastomeric block copolymer poly (styrene‐block …

Development of a molecularly imprinted polymer-based electrochemical sensor for the selective detection of nerve agent VX metabolite ethyl methylphosphonic acid …

S Sezigen, SI Kaya, NK Bakirhan, SA Ozkan - Analytical and Bioanalytical …, 2024 - Springer
This study focuses on the detection of ethyl methyl phosphonic acid (EMPA), a metabolite of
the banned organophosphorus nerve agent VX. We developed an electrochemical sensor …

Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: electrophoretic and mass spectrometric identification and characterization

W Schmeißer, R Lüling, D Steinritz… - Drug Testing and …, 2022 - Wiley Online Library
For the verification of exposure to the banned blister agent sulfur mustard (SM) and the
better understanding of its pathophysiology, protein adducts formed with endogenous …