Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Sex differences may play a critical role in modulating how chronic or heavy alcohol use
impacts the brain to cause the development of alcohol use disorder (AUD). AUD is a …

JCI - Preclinical and clinical evidence for suppression of alcohol intake by apremilast Go to
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Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

What individual differences in neural activity predict the future escalation of alcohol drinking
from casual to compulsive? The neurobiological mechanisms that gate the transition from …

Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Alcohol use disorder remains a substantial social, health, and economic problem and
problem drinking levels in women have been increasing in recent years. Understanding …

Background Alcohol use disorder is characterized by compulsive alcohol intake, or drinking
despite negative consequences. Previous studies have shown that female rodents have a …

Compulsive tendencies are a central feature of problematic human behavior and thereby
are of great interest to the scientific and clinical community. However, no consensus exists …

Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical
and psychiatric conditions such as forms of obesity and eating disorders. Although feeding …