[HTML][HTML] Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

L Galluzzi, I Vitale, S Warren, S Adjemian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

Quo vadis oncological hyperthermia (2020)?

SY Lee, G Fiorentini, AM Szasz, G Szigeti… - Frontiers in …, 2020 - frontiersin.org
Heating as a medical intervention in cancer treatment is an ancient approach, but effective
deep heating techniques are lacking in modern practice. The use of electromagnetic …

Hyperthermia targeting the tumor microenvironment facilitates immune checkpoint inhibitors

Z Li, J Deng, J Sun, Y Ma - Frontiers in Immunology, 2020 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have ushered in a new era of cancer therapy; however,
ICIs are only effective in selective patients. The efficacy of ICIs is closely related to the tumor …

Modulated electro-hyperthermia-induced tumor damage mechanisms revealed in cancer models

T Krenacs, N Meggyeshazi, G Forika, E Kiss… - International journal of …, 2020 - mdpi.com
The benefits of high-fever range hyperthermia have been utilized in medicine from the
Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia …

The effects of localized heat on the hallmarks of cancer

G Hannon, FL Tansi, I Hilger… - Advanced …, 2021 - Wiley Online Library
Heat has been used to treat tumors for thousands of years. There are reports of the
Egyptians and Greek philosophers using such treatments as far back as 3000 BC and 500 …

Forcing the antitumor effects of HSPs using a modulated electric field

CA Minnaar, A Szasz - Cells, 2022 - mdpi.com
The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors.
The location and interactions of HSPs determine their pro-or antitumor activity. The present …

Synergy between TMZ and individualized multimodal immunotherapy to improve overall survival of IDH1 wild-type MGMT promoter-unmethylated GBM patients

SW Van Gool, J Makalowski, M Bitar, P Van de Vliet… - Genes & …, 2022 - nature.com
The prognosis of IDH1 wild-type MGMT promoter-unmethylated GBM patients remains poor.
Addition of Temozolomide (TMZ) to first-line local treatment shifted the median overall …

[HTML][HTML] A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung …

J Ou, X Zhu, P Chen, Y Du, Y Lu, X Peng, S Bao… - Journal of Advanced …, 2020 - Elsevier
Our previous study indicated that intravenous vitamin C (IVC) treatment concurrent with
modulated electrohyperthermia (mEHT) was safe and improved the quality of life (QoL) of …

Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model

PHL Viana, CA Schvarcz, LO Danics, B Besztercei… - Scientific Reports, 2024 - nature.com
Female breast cancer is the most diagnosed cancer worldwide. Triple negative breast
cancer (TNBC) is the most aggressive type and there is no existing endocrine or targeted …

Potentiation of the abscopal effect by modulated electro-hyperthermia in locally advanced cervical cancer patients

CA Minnaar, JA Kotzen, OA Ayeni, MDT Vangu… - Frontiers in …, 2020 - frontiersin.org
Background: A Phase III randomized controlled trial investigating the addition of modulated
electro-hyperthermia (mEHT) to chemoradiotherapy for locally advanced cervical cancer …