Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Sexual dimorphism is a key factor to consider in the ageing process given the impact that it
has on life expectancy. The oxidative-inflammatory theory of ageing states that the ageing …

Stroke is a leading cause of death and disability worldwide. Women are disproportionately
affected by stroke, exhibiting higher mortality and disability rates post-stroke than men …

Inflammasomes are intracellular signaling complexes of the innate immune system, which is
part of the response to exogenous pathogens or physiological aberration. The multiprotein …

Acute liver injury (ALI) is a poor prognosis and high mortality complication of sepsis.
Paeoniflorin (PF) has remarkable anti‐inflammatory effects in different disease models …

The cardiovascular (CV) benefit and safety of treating low testosterone conditions is a matter
of debate. Although testosterone deficiency has been linked to a rise in major adverse CV …

The NLRP3 inflammasome is a crucial constituent of the body's innate immune system, and
a multiprotein platform which is initiated by pattern recognition receptors (PRRs). Its …

COVID-19 is a pandemic disease caused by severe acute respiratory coronavirus 2 (SARS-
CoV-2), which leads to pulmonary manifestations like acute lung injury (ALI) and acute …

Background Polycystic ovary syndrome (PCOS) is a common clinical disease often
associated with insulin resistance (IR). The interaction between PCOS and IR will promote …

The importance of sex differences is increasingly acknowledged in the incidence and
treatment of disease. Accumulating clinical evidence demonstrates that sex differences are …