[HTML][HTML] Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation
CB Collin, T Gebhardt, M Golebiewski… - Journal of personalized …, 2022 - mdpi.com
The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …
different sources, as well as harmonized integrative analysis of large-scale clinical health …
SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update
P Lo Surdo, M Iannuccelli, S Contino… - Nucleic acids …, 2023 - academic.oup.com
Abstract The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor. uniroma2. it) is
a public repository that captures causal information and represents it according to an 'activity …
a public repository that captures causal information and represents it according to an 'activity …
Network medicine: an approach to complex kidney disease phenotypes
AK Pandey, J Loscalzo - Nature Reviews Nephrology, 2023 - nature.com
Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …
more than a century. However, the reductionist approach of characterizing diseases from a …
[HTML][HTML] Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment
H Misetic, MR Keddar, JP Jeannon, FD Ciccarelli - Genome Medicine, 2023 - Springer
Background The crosstalk between cancer and the tumour immune microenvironment
(TIME) has attracted significant interest in the latest years because of its impact on cancer …
(TIME) has attracted significant interest in the latest years because of its impact on cancer …
Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions
The versatility of cellular response arises from the communication, or crosstalk, of signaling
pathways in a complex network of signaling and transcriptional regulatory interactions …
pathways in a complex network of signaling and transcriptional regulatory interactions …
[HTML][HTML] Curation of causal interactions mediated by genes associated with autism accelerates the understanding of gene-phenotype relationships underlying …
Autism spectrum disorder (ASD) comprises a large group of neurodevelopmental conditions
featuring, over a wide range of severity and combinations, a core set of manifestations …
featuring, over a wide range of severity and combinations, a core set of manifestations …
[HTML][HTML] The impaired wound healing process is a major factor in remodeling of the corneal epithelium in adult and adolescent patients with keratoconus
K Jaskiewicz, M Maleszka-Kurpiel… - … & Visual Science, 2023 - jov.arvojournals.org
Purpose: Keratoconus (KTCN) is the most common corneal ectasia, characterized by
pathological cone formation. Here, to provide an insight into the remodeling of the corneal …
pathological cone formation. Here, to provide an insight into the remodeling of the corneal …
konnect2prot: a web application to explore the protein properties in a functional protein–protein interaction network
Motivation The regulation of proteins governs the biological processes and functions and,
therefore, the organisms' phenotype. So there is an unmet need for a systematic tool for …
therefore, the organisms' phenotype. So there is an unmet need for a systematic tool for …
[PDF][PDF] EU-STANDS4PM consortium; et al. Computational models for clinical applications in personalized medicine—Guidelines and recommendations for data …
The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …
different sources, as well as harmonized integrative analysis of large-scale clinical health …
[HTML][HTML] Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization
Treatment with combinations of drugs carries great promise for personalized therapy for a
variety of diseases. We have previously shown that synergistic combinations of cancer …
variety of diseases. We have previously shown that synergistic combinations of cancer …