Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …

From growing cells in spheroids to arranging them on complex engineered scaffolds, three-
dimensional cell culture protocols are rapidly expanding and diversifying. While these …

It is of great value to develop reliable in vitro models for cell biology and toxicology.
However, ethical issues and the decreasing number of donors restrict the further use of …

In early preclinical drug development, potential candidates are tested in the laboratory using
isolated cells. These in vitro experiments traditionally involve cells cultured in a two …

The cell spheroid technology, which greatly enhances cell-cell interactions, has gained
significant attention in the development of in vitro liver models. However, existing cell …

Mitochondrial toxicity (Mito-Tox) risk has increased due to the administration of several
classes of drugs, particularly some life-long antiretroviral drugs for HIV+ individuals …

Drug induced liver injury (DILI) is one of the major reasons of drug withdrawal during the
different phases of drug development. The later in the drug development a drug is …

Cancer continues to be a leading cause of mortality in modern societies; therefore, improved
and more reliable in vitro cancer models are needed to expedite fundamental research and …

Organotypic three‐dimensional liver spheroid cultures in which hepatic cells retain their
molecular phenotype and functionality have emerged as powerful tools for preclinical drug …