Nasally inhaled therapeutics and vaccination for COVID‐19: Developments and challenges
J Xi, LR Lei, W Zouzas, X April Si - MedComm, 2021 - Wiley Online Library
The nose is the initial site of viral infection, replication, and transmission in the human body.
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …
[HTML][HTML] Mathematical and computer modeling as a novel approach for the accelerated development of new inhalation and intranasal drug delivery systems
N Menshutina, A Abramov, E Mokhova - Computation, 2023 - mdpi.com
This paper presents modern methods of mathematical modeling, which are widely used in
the development of new inhalation and intranasal drugs, including those necessary for the …
the development of new inhalation and intranasal drugs, including those necessary for the …
[HTML][HTML] SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry
When an infected person coughs, many virus-laden droplets will be exhaled out of the
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
[HTML][HTML] Radiation dosimetry of inhaled radioactive aerosols: CFPD and MCNP transport simulations of radionuclides in the lung
Despite extensive efforts in studying radioactive aerosols, including the transmission of
radionuclides in different chemical matrices throughout the body, the internal organ-specific …
radionuclides in different chemical matrices throughout the body, the internal organ-specific …
Nasal dilation effects on olfactory deposition in unilateral and bi-directional deliveries: In vitro tests and numerical modeling
The human nose can expand either actively or passively to increase airflow. Nasal dilation
may alter drug delivery efficiencies in the nasal airway or olfactory region. However, the …
may alter drug delivery efficiencies in the nasal airway or olfactory region. However, the …
Targeted drug delivery to the inferior meatus cavity of the nasal airway using a nasal spray device with angled tip
Abstract Background and Objective: Nowadays, by advancement in computational tools,
Computational Fluid and Particle Dynamics (CFPD) technique can be used more than ever …
Computational Fluid and Particle Dynamics (CFPD) technique can be used more than ever …
Visualization of local deposition of nebulized aerosols in a human upper respiratory tract model
Knowing aerosol deposition distribution (ADD) in the respiratory tract is crucial in assessing
dose–response relationship and optimizing inhalation therapy. However, characterization of …
dose–response relationship and optimizing inhalation therapy. However, characterization of …
Understanding the mechanisms underlying pulsating aerosol delivery to the maxillary sinus: in vitro tests and computational simulations
Background Pulsating aerosol delivery has been demonstrated in depositing medications
into paranasal sinuses. However, its mechanisms are not fully understood. Influences of the …
into paranasal sinuses. However, its mechanisms are not fully understood. Influences of the …
Count-and mass-based dosimetry of MDI spray droplets with polydisperse and monodisperse size distributions
Most previous numerical studies of inhalation drug delivery used monodisperse aerosols or
quantified deposition as the ratio of deposited particle number over the total number of …
quantified deposition as the ratio of deposited particle number over the total number of …
Alveolar size effects on nanoparticle deposition in rhythmically expanding-contracting terminal alveolar models
Significant differences in alveolar size exist in humans of different ages, gender, health, and
among different species. The effects of alveolar sizes, as well as the accompanying …
among different species. The effects of alveolar sizes, as well as the accompanying …