Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion in
the HD gene. The disease is characterized by neurodegeneration, particularly in the striatum …

AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase
group, is universally distributed in various cells and organs. It is a significant endogenous …

Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Spinal cord injury (SCI) is one kind of severe trauma for central nervous system. Myelin
debris clearance and axon regeneration are essential for nerve regeneration after SCI …

Introduction: Metformin is currently first line therapy for type 2 diabetes (T2D). The
mechanism of action of metformin involves activation of AMP-activated protein kinase …

Spinal cord injury (SCI) is a devastating disease that may lead to lifelong disability. Thus,
seeking for valid drugs that are beneficial to promoting axonal regrowth and elongation after …

Neurodegenerative diseases are disorders that are characterized by a progressive decline
of motor and/or cognitive functions caused by the selective degeneration and loss of …

Metformin, one of the first-line of hypoglycemic drugs, has cardioprotective, anti-
inflammatory and anticancer activities, in addition to its proven hypoglycemic effects …

Spinal cord injury (SCI) is a severe neurological disease with few efficacious drugs.
Autophagy is a cellular process to confront with stress after SCI and considered to be a …