Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

The stimulation of dopamine receptors via an increased concentration of synaptic dopamine
levels in the mesocorticolimbic regions of the brain has been defined as the primary …

Hydroaminomethylation (HAM) of olefins constitutes one of the most promising and practical
methods to produce amines, but control of the selectivity between linear and branched …

Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics
for several neuropsychiatric disorders including schizophrenia (antagonists) and …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Aggregation of alpha synuclein (α-syn) leading to dopaminergic neuronal death has been
recognized as one of the main pathogenic factors in the initiation and progression of …

The role of iron in the pathogenesis of Parkinson's disease (PD) has been implicated
strongly because of generation of oxidative stress leading to dopamine cell death. In our …

Parkinson's disease (PD) is the second common neurodegenerative disease characterized
by movement disorder. The symptoms of PD harm both the physical and mental health of …