We conducted a systematic review and meta-analysis to determine the effect of acute
poikilocapnic, high-altitude, and acute isocapnia hypoxemia on muscle sympathetic nerve …

Sympathoexcitation is a hallmark of hypoxic exposure, occurring acutely, as well as
persisting in acclimatised lowland populations and with generational exposure in highland …

Type H vessels couple angiogenesis with osteogenesis, while sympathetic cues regulate
vascular and skeletal function. The crosstalk between sympathetic nerves and type H …

Hypoxic exposure makes plateau migrators susceptible to high altitude polycythemia
(HAPC). Astragalus membranaceus (AM) is an edible and medicinal plant with remarkable …

BACKGROUND: The mechanisms underlying pulmonary hypertension (PH) remain largely
unknown; further, why advanced vascular remodeling preferentially occurs in arterioles is …

Background: In large-scale genomic studies, Sox17, an endothelial-specific transcription
factor, has been suggested as a putative causal gene of pulmonary arterial hypertension …

Key points Humans suffering from polycythaemia undergo multiple circulatory adaptations
including changes in blood rheology and structural and functional vascular adaptations to …

Background Since vascular responses to hypoxia in both healthy high-altitude natives and
chronic mountain sickness (a maladaptive high-altitude pathology characterised by …

High-altitude exposure typically reduces endothelial function, and this is modulated by
hemoconcentration resulting from plasma volume contraction. However, the specific impact …

Mitochondria-derived oxidative stress during fetal development increases cardiovascular
risk in adult offspring of pregnancies complicated by chronic fetal hypoxia. We investigated …