Spray drying: Inhalable powders for pulmonary gene therapy
Gene therapy holds potential in the treatment of many lung pathologies, as indicated by the
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …
Formulation of RNA interference-based drugs for pulmonary delivery: challenges and opportunities
With recent advances in the field of RNAi-based therapeutics, it is possible to make any
target gene 'druggable', at least in principle. The present review focuses on aspects critical …
target gene 'druggable', at least in principle. The present review focuses on aspects critical …
Selective nonsteroidal glucocorticoid receptor modulators for the inhaled treatment of pulmonary diseases
M Hemmerling, S Nilsson, K Edman… - Journal of Medicinal …, 2017 - ACS Publications
A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor
modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases …
modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases …
Inhaled formulation and device selection: bridging the gap between preclinical species and first-in-human studies
JL Wylie, A House, PJ Mauser, S Sellers… - Therapeutic …, 2018 - Taylor & Francis
The factors that influence inhaled first-in-human (FIH) device and formulation selection often
differ significantly from the factors that have influenced the preceding preclinical experiments …
differ significantly from the factors that have influenced the preceding preclinical experiments …