Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy

F Galli, JV Aguilera, B Palermo, SN Markovic… - Journal of experimental …, 2020 - Springer
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …

[HTML][HTML] Novel PET imaging of inflammatory targets and cells for the diagnosis and monitoring of giant cell arteritis and polymyalgia rheumatica

KSM van der Geest, M Sandovici, PH Nienhuis… - Frontiers in …, 2022 - frontiersin.org
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers

CH Mayr, LM Simon, G Leuschner, M Ansari… - EMBO molecular …, 2021 - embopress.org
The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

E Conte - Pharmacology & Therapeutics, 2022 - Elsevier
Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Imaging inflammation with positron emission tomography

J Iking, M Staniszewska, L Kessler, JM Klose… - Biomedicines, 2021 - mdpi.com
The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation

PK Moore, KC Anderson… - … of Physiology-Lung …, 2023 - journals.physiology.org
Interstitial macrophages (IMs) reside in the lung tissue surrounding key structures including
airways, vessels, and alveoli. Recent work has described IM heterogeneity during …

Folate receptor beta for macrophage imaging in rheumatoid arthritis

MM Steinz, A Ezdoglian, F Khodadust… - Frontiers in …, 2022 - frontiersin.org
Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and
therapy response monitoring of patients with autoimmune diseases, including rheumatoid …

Functionally heterogenous macrophage subsets in the pathogenesis of giant cell arteritis: novel targets for disease monitoring and treatment

I Esen, WF Jiemy, Y van Sleen… - Journal of Clinical …, 2021 - mdpi.com
Giant cell arteritis (GCA) is a granulomatous large-vessel vasculitis that affects adults above
50 years of age. In GCA, circulating monocytes are recruited to the inflamed arteries. With …

Monitoring of current cancer therapy by positron emission tomography and possible role of radiomics assessment

N Oriuchi, H Endoh, K Kaira - International Journal of Molecular Sciences, 2022 - mdpi.com
Evaluation of cancer therapy with imaging is crucial as a surrogate marker of effectiveness
and survival. The unique response patterns to therapy with immune-checkpoint inhibitors …

[HTML][HTML] Novel tracers for molecular imaging of interstitial lung disease: A state of the art review

B Broens, JW Duitman, GJC Zwezerijnen… - Autoimmunity …, 2022 - Elsevier
Interstitial lung disease is an overarching term for a wide range of disorders characterized by
inflammation and/or fibrosis in the lungs. Most prevalent forms, among others, include …