Challenges and opportunities for digital twins in precision medicine: a complex systems perspective

M De Domenico, L Allegri, G Caldarelli… - arXiv preprint arXiv …, 2024 - arxiv.org
The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by
extensive data collection and advancements in artificial intelligence (AI), alongside …

myAURA: Personalized health library for epilepsy management via knowledge graph sparsification and visualization

RB Correia, JC Rozum, L Cross, J Felag… - arXiv preprint arXiv …, 2024 - arxiv.org
Objective: We report the development of the patient-centered myAURA application and suite
of methods designed to aid epilepsy patients, caregivers, and researchers in making …

Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

J Bowman, N Silva, E Schüueftan, JM Almeida… - bioRxiv, 2023 - biorxiv.org
Gorillas have a polygynous social system in which the highest-ranking male has almost
exclusive access to females and sires most of the offspring in the troop. Such behavior …

Regulatory changes associated with the head to trunk developmental transition

P Duarte, R Brattig Correia, A Nóvoa, M Mallo - BMC biology, 2023 - Springer
Background Development of vertebrate embryos is characterized by early formation of the
anterior tissues followed by the sequential extension of the axis at their posterior end to build …

[HTML][HTML] Dynamical modularity in automata models of biochemical networks

T Parmer, LM Rocha - ArXiv, 2023 - ncbi.nlm.nih.gov
Given the large size and complexity of most biochemical regulation and signaling networks,
there is a non-trivial relationship between the micro-level logic of component interactions …

The ultrametric backbone is the union of all minimum spanning forests

JC Rozum, LM Rocha - Journal of Physics: Complexity, 2024 - iopscience.iop.org
Minimum spanning trees and forests are powerful sparsification techniques that remove
cycles from weighted graphs to minimize total edge weight while preserving node …

Shifting Gears: Insights into the Head to Trunk Transition Exploring the Regulatory Changes Underlying the Head to Trunk Developmental Transition

P Duarte - 2023 - search.proquest.com
Although vertebrates display a wide diversity of body shapes and sizes their basic body plan
is consistently organized into head, neck, trunk and tail structures. During development, the …

[PDF][PDF] Shifting gears: Insights into the head to trunk transition

P Duarte - run.unl.pt
To Moisés for the opportunity of joining the lab and working on this project, thank you for
your guidance and support. To all the past and present members of the lab I had the …