Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Gram-negative bacterial pathogens have an outer membrane that restricts entry of
molecules into the cell. Water-filled protein channels in the outer membrane, so-called …

Gram-negative bacteria can resist antibiotics by changing the permeability via their outer
membrane. These bacteria have a complex cell envelope that incorporates an outer …

Abstract Objectives Salmonella enterica serovar Typhimurium is one of the significant non-
typhoidal Salmonella serovars that causes gastroenteritis. The rapid development of …

The emergence of multidrug-resistant pathogens led to a critical need for new antibiotics. A
key property of effective antibiotics against Gram-negative bacteria is their ability to …

Antibiotics enter into bacterial cells via protein channels that serve as low-energy pathways
through the outer membrane, which is otherwise impenetrable. Insights into the molecular …

Efficient permeation into Gram-negative bacterial cells is a much-desired property in the
design of antibacterial agents. The goal is to arrive at one or more chemical modifications of …

We explored the antibacterial potential (alone and combination) against multidrug resistant
(MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno [3, 2-c] pyran-2 …