The splicing of pre‐mRNAs is an essential step of gene expression in eukaryotes. Introns
are removed from split genes through the activities of the spliceosome, a large ribonuclear …

Alternative splicing of mRNA precursors enables one gene to produce multiple protein
isoforms with differing functions. Under normal conditions, this mechanism is tightly …

Despite the many approaches to study differential splicing from RNA-seq, many challenges
remain unsolved, including computing capacity and sequencing depth requirements. Here …

Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs).
Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most …

Through alternative splicing, most human genes express multiple isoforms that often differ in
function. To infer isoform regulation from high-throughput sequencing of cDNA fragments …

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …

Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic
development, plays a critical role during malignant transformation. While much is known …

KRAS mutations are causally linked to protumor inflammation and are identified as driving
factors in tumorigenesis. Here, using multiomics data gathered from a large set of patients …

Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying
molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 …

In alternative expression analysis by sequencing (ALEXA-seq), we developed a method to
analyze massively parallel RNA sequence data to catalog transcripts and assess differential …