Malaria: influence of Anopheles mosquito saliva on Plasmodium infection
Malaria is caused by Plasmodium protozoa that are transmitted by anopheline mosquitoes.
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …
Plasmodium sporozoites on the move: Switching from cell traversal to productive invasion of hepatocytes
M Loubens, L Vincensini, P Fernandes… - Molecular …, 2021 - Wiley Online Library
Parasites of the genus Plasmodium, the etiological agent of malaria, are transmitted through
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …
the bite of anopheline mosquitoes, which deposit sporozoites into the host skin. Sporozoites …
A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …
immunology analyses and controlled human infection models to define the protective …
A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection
SC Murphy, AM Vaughan, JG Kublin… - Science translational …, 2022 - science.org
Genetically engineered live Plasmodium falciparum sporozoites constitute a potential
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …
platform for creating consistently attenuated, genetically defined, whole-parasite vaccines …
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
[HTML][HTML] Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
MC Aguirre-Botero, LT Wang, P Formaglio… - Cell reports, 2023 - cell.com
Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …
Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein
LT Wang, LS Pereira, PK Kiyuka, A Schön… - PLoS …, 2021 - journals.plos.org
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same
antigen synergistically neutralize many viruses. However, there are limited studies …
antigen synergistically neutralize many viruses. However, there are limited studies …
The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo
Y Flores-Garcia, LT Wang, M Park, B Asady… - PLoS …, 2021 - journals.plos.org
Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf)
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …
An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein
L Jelínková, H Jhun, A Eaton, N Petrovsky, F Zavala… - npj Vaccines, 2021 - nature.com
A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …