Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Jumonji C domain-containing (JMJD) proteins are mostly epigenetic regulators that
demethylate histones. However, a hitherto neglected subfamily of JMJD proteins …

Abstract Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub
for diverse signaling pathways to regulate gene expression. Because gene expression is …

The CDK8/19 kinase module comprises a subcomplex that interacts with the Mediator
complex and regulates gene expression through phosphorylation of transcription factors and …

Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic
integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying …

Background The androgen receptor (AR) is a major driver of prostate cancer, and increased
AR levels and co-activators of the receptor promote the development of prostate cancer …

Epigenetic regulation refers to the alteration of gene expression independent of changes in
DNA sequence. It involves chemical modifications such as DNA methylation, histone …

Increasing evidence has proved the pivotal roles of androgen receptor in various diseases,
including prostate cancer and bladder cancer. The CD24 has been proved to be correlated …

Short linear motifs (SLiMs) are evolutionarily conserved functional modules of proteins that
represent amino acid stretches composed of 3 to 10 residues. The biological activities of two …

Objective Glioblastoma (GB) is a refractory malignancy with a high rate of recurrence and
treatment resistance. Hypoxia-related genes are promising prognostic indicators for GB, so …